Safety studies in miceSafety studies to test the pathogenicity of the live oral rabies vaccine strains ORA-DP and ORA-DPC. Method
The following groups of mice were injected with the different vaccine strains intramuscularly (two vaccine doses two weeks apart):
- 2 day old mice
- 1 week old mice
- Immuno-incompetent mice
Results Pathogenicity of Adapted Rabies Viruses in Suckling Mice
Pathogenicity of Adapted Rabies Viruses in Nude and SCID Mice Conclusion
ORA-DP and ORA-DPC vaccine viruses are safe in very susceptible immuno-compromised mice and 2-day old suckling mice. top Safety and efficacy studies in dogsStudies to test the efficacy and efficacy of ORA-DP and ORA-DPC in immuno-compromised and immuno-competent dogs. Method - Two groups of beagle dogs 4 months of age were used.
- Group 1: treated with dexadresson (0.5 mg/kg body weight) by
subcutaneous injection, 3 times per week three months.
- Group 2: untreated
- Vaccine virus
(108 FFU) was given orally the first week and a booster vaccination at 8 weeks
after starting the corticosteroid treatment to both groups.
- Both groups of dogs were observed for general health conditions and behavioral
change.
- Virus isolation: attempted from from saliva samples of vaccinated dogs from both groups.
- Serology: Sera samples from both groups were collected for antibody analysis
Results - No rabies related signs or adverse reactions were detected throughout the observation period of three months. No vaccine virus could be isolated from the saliva of the dogs post inoculation.
- Safety and Efficacy of ORA-DP/-DPC in Dogs. Antibody response (IU/ml)
Conclusion - ORA-DP and ORA-DPC vaccine viruses are safe, even in immuno-compromised dogs.
- ORA-DPC is highly effective for the oral immunization of dogs.
For details of these safety and efficacy studies see complete article:
Development of an Oral Rabies Vaccine with improved safety and efficacy to control Canine Rabies in ownerless and stray dogs (pdf 142 kb)
T.Mebatsion, S. Kilari, N.Visser. top | 
